Nagato Hajime, Umebayashi Yoshihiro, Wako Masahiko, Tabata Yasuhiko, Manabe Motomu
Department of Dermatology and Plastic Surgery, Akita University School of Medicine, Hondo 1-1-1, Akita-shi, Akita 010-8543, Japan.
J Dermatol. 2006 Oct;33(10):670-5. doi: 10.1111/j.1346-8138.2006.00157.x.
Because poor skin wound healing associated with diabetes is thought to be partly a result from impaired angiogenesis, treatments that improve angiogenesis could have important clinical applications. We herein report the effects of novel developed material, collagen-poly glycolic acid fiber hybrid matrix, being used together with basic fibroblast growth factor to promote wound healing of full-thickness skin defects on the back of type 2 diabetic Lepr(db) mice. Our data indicates that this therapeutic approach markedly promotes angiogenesis and granulation tissue formation in comparison with other conditions 14 days after wounding.
由于糖尿病相关的皮肤伤口愈合不良被认为部分是血管生成受损的结果，改善血管生成的治疗方法可能具有重要的临床应用价值。我们在此报告新开发的材料——胶原-聚乙醇酸纤维混合基质，与碱性成纤维细胞生长因子一起使用，对2型糖尿病Lepr(db)小鼠背部全层皮肤缺损伤口愈合的促进作用。我们的数据表明，与其他情况相比，这种治疗方法在伤口形成14天后能显著促进血管生成和肉芽组织形成。
