Fulford A J, Webster M, Ouma J H, Kimani G, Dunne D W
Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge, UK CB2 1QP.
Parasitol Today. 1998 Jan;14(1):23-6. doi: 10.1016/s0169-4758(97)01168-x.
Recent data from outbreaks of schistosomiasis in immunologically naive populations have refuelled the debate concerning the nature or existence of protective, acquired immunity to schistosomiasis in humans. Data from endemic communities provide some compelling evidence for an abrupt change in reinfection rates that coincides with puberty. We suggest that the hormonal changes of adrenarche may hold the key to understanding the relative resistance to infection found in adults.
近期在无免疫经验人群中爆发的血吸虫病数据，再次引发了关于人类对血吸虫病的保护性获得性免疫的性质或存在与否的争论。来自流行社区的数据提供了一些令人信服的证据，表明再感染率在青春期时会突然发生变化。我们认为，肾上腺初现的激素变化可能是理解成年人对感染具有相对抵抗力的关键。
