Galanti N, Galindo M, Sabaj V, Espinoza I, Toro G C
Parasitol Today. 1998 Feb;14(2):64-70. doi: 10.1016/s0169-4758(97)01162-9.
Histone genes in Trypanosomatids are of considerable interest because these flagellates do not condense their chromatin during mitosis. In contrast to higher eukaryotes, histone genes in Trypanosomatids are found on separate chromosomes, and their transcripts are polyadenylated. Sequence similarity of Trypanosomatid core histones with those of higher eukaryotes is found predominantly in the globular region; the N-terminal is highly divergent. Finally, in general, Trypanosomatid histones H1 are of low molecular weight, bearing closest homology to the C-terminal region of the higher eukaryote histones H1. These features constitute interesting targets for a rational approach to the study of these protozoa, as discussed here by Norbel Galanti and colleagues.
锥虫中的组蛋白基因备受关注，因为这些鞭毛虫在有丝分裂期间不会使染色质浓缩。与高等真核生物不同，锥虫中的组蛋白基因位于不同的染色体上，并且它们的转录本是多聚腺苷酸化的。锥虫核心组蛋白与高等真核生物的核心组蛋白的序列相似性主要存在于球状区域；N 端差异很大。最后，一般来说，锥虫组蛋白 H1 的分子量较低，与高等真核生物组蛋白 H1 的 C 端区域具有最密切的同源性。正如诺贝尔·加兰蒂及其同事在此所讨论的，这些特征构成了对这些原生动物进行合理研究方法的有趣靶点。
