Spithill T W, Dalton J P
Department of Biochemistry and Molecular Biology, Monash University, Monash Australia.
Parasitol Today. 1998 Dec;14(6):224-8. doi: 10.1016/s0169-4758(98)01245-9.
Infection of ruminants by Fasciola spp continues to cause large economic losses worldwide. Recent results from several laboratories have demonstrated that animals can be significantly protected against infection by vaccination with defined Fasciola antigens. Apart from reducing fluke burdens, some vaccines can elicit a concurrent reduction in parasite egg production. The expectation of a commercially feasible vaccine that might also reduce parasite transmission in the field is now realistic, although major hurdles still exist. Here, Terry Spithill and John Dalton review the results of several recent vaccine trials and discuss the future prospects for vaccine development.
片形吸虫属对反刍动物的感染在全球范围内持续造成巨大经济损失。多个实验室最近的结果表明，通过接种特定的片形吸虫抗原，动物可得到显著的感染防护。除了减轻吸虫负担外，一些疫苗还能同时减少寄生虫的产卵量。尽管仍然存在重大障碍，但开发一种在商业上可行且可能减少田间寄生虫传播的疫苗的期望现在已成为现实。在此，特里·斯皮蒂尔和约翰·道尔顿回顾了最近几次疫苗试验的结果，并讨论了疫苗开发的未来前景。
