Sutherland C J
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT.
Parasitol Today. 1998 Aug;14(8):329-32. doi: 10.1016/s0169-4758(98)01276-9.
In areas where Plasmodium falciparum is endemic, the natural immunity acquired by people exposed to frequent malaria infection is likely to have a differential selective impact upon different parasite genotypes. It has been suggested that the immune response directed against the variant antigen PfEMP1, which is expressed on the infected erythrocyte surface, is a crucial determinant of parasite population structure and favours the existence of distinct strains, or Varotypes. Here, Colin Sutherland summarizes current knowledge of the var multigene family, which encodes the PfEMP1 variants, and suggests that this information may allow certain predictions of the strain hypothesis to be tested directly.
在恶性疟原虫流行的地区，经常接触疟疾感染的人所获得的自然免疫力可能会对不同的寄生虫基因型产生不同的选择性影响。有人提出，针对感染红细胞表面表达的变异抗原PfEMP1的免疫反应是寄生虫种群结构的关键决定因素，有利于不同菌株或变种型的存在。在这里，科林·萨瑟兰总结了编码PfEMP1变体的var多基因家族的现有知识，并表明这些信息可能使对菌株假说的某些预测能够得到直接检验。
