Knoll L J, Boothroyd J C
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA.
Parasitol Today. 1998 Dec;14(12):490-3. doi: 10.1016/s0169-4758(98)01347-7.
Within intermediate hosts (such as humans), the protozoan parasite Toxoplasma gondii has two life cycle stages: a rapidly replicating form called a tachyzoite and a slowly growing, quiescent form called a bradyzoite. Recently, molecular biology studies have shown that tachyzoites and bradyzoites express a number of homologs (ie. evolutionary related genes)expressed exclusively in one or the other stage. Here, Laura Knoll and John Boothroyd describe examples of how these stage-specific homologs were discovered, and speculate about their regulation and functional significance.
在中间宿主（如人类）中，原生动物寄生虫刚地弓形虫有两个生命周期阶段：一种快速复制的形式称为速殖子，另一种生长缓慢、静止的形式称为缓殖子。最近，分子生物学研究表明，速殖子和缓殖子表达了许多仅在一个阶段或另一个阶段特异性表达的同源物（即进化相关基因）。在这里，劳拉·诺尔和约翰·布斯罗伊德描述了这些阶段特异性同源物是如何被发现的例子，并推测了它们的调控和功能意义。
