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在一名无类风湿关节炎关节表现的患者中,出现模仿恶性肺部疾病的空洞性坏死结节。

Cavitary necrobiotic nodule imitating malignant lung disease in a patient without articular manifestations of rheumatoid arthritis.

作者信息

Karadag Fisun, Polatli Mehmet, Senturk Taskin, Kacar Furuzan, Sen Serdar, Cildag Orhan

机构信息

Departments of Chest Diseases, Adnan Menderes University, School of Medicine, Aydin, Turkey.

出版信息

J Clin Rheumatol. 2003 Aug;9(4):246-52. doi: 10.1097/01.rhu.0000081260.50171.bf.

Abstract

Pulmonary involvement is a serious complication of rheumatoid arthritis (RA) and may be seen as airway disease, rheumatoid nodules, interstitial lung disease, and pleurisy. However, cavitary rheumatoid nodules without articular manifestations are rare. We describe a male patient presenting with pleurisy and multiple rheumatoid necrobiotic nodules in the absence of arthritis or subcutaneous nodules. One of the nodules was quite large (5 x 8 cm in diameter) and cavitary, imitating bronchial carcinoma radiologically and bronchoscopically. Definite histopathologic diagnosis was obtained by open lung biopsy. The patient was given methylprednisolone and methotrexate, and significant regression was observed in clinical and radiologic findings. He has been followed for 14 months with no articular manifestations yet, receiving 4 mg/d methylprednisolone and 20 mg/wk methotrexate. The diagnosis of rheumatoid pulmonary involvement without articular manifestations can be difficult. Rheumatoid nodules may imitate bronchial carcinoma, or bronchial carcinoma may coexist in RA patients. Open lung biopsy may be necessary for differential diagnosis of pulmonary lesions in RA.

摘要

肺部受累是类风湿关节炎(RA)的一种严重并发症,可表现为气道疾病、类风湿结节、间质性肺疾病和胸膜炎。然而,无关节表现的空洞性类风湿结节较为罕见。我们描述了一名男性患者,该患者在无关节炎或皮下结节的情况下出现胸膜炎和多个类风湿坏死性结节。其中一个结节相当大(直径5×8厘米)且有空洞,在影像学和支气管镜检查中形似支气管癌。通过开胸肺活检获得了明确的组织病理学诊断。给予患者甲泼尼龙和甲氨蝶呤治疗后,临床和影像学表现均有显著改善。对其随访14个月,尚无关节表现,目前患者接受每日4毫克甲泼尼龙和每周20毫克甲氨蝶呤的治疗。无关节表现的类风湿肺部受累的诊断可能较为困难。类风湿结节可能形似支气管癌,或者支气管癌可能与RA患者并存。对于RA患者肺部病变的鉴别诊断,开胸肺活检可能是必要的。

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