Savin G A
Bioorg Khim. 2006 Sep-Oct;32(5):546-50.
New phospholipids, thio- and selenoanalogues of phosphatidic acids, were synthesized on the basis of 2,2,5,5-tetra(hydroxymethyl)cyclopentanone. The starting tetraol monoketal was phosphorylated with amidophosphorous acid chlorides to protected polyol amidophosphites, which were further sulfurized or selenized to phosphoacetals. These were directly acylated with fatty acid chlorides to thio- and selenoanalogues of phospholipids.
基于2,2,5,5-四（羟甲基）环戊酮合成了新型磷脂、磷脂酸的硫代和硒代类似物。起始四醇单缩酮用亚磷酰氯进行磷酸化反应生成受保护的多元醇亚磷酰胺酯，然后进一步硫化或硒化生成磷缩醛。这些产物直接用脂肪酸氯化物酰化生成磷脂的硫代和硒代类似物。
