MacDermott J P, Charpied G C, Tesluk H, Stone A R
Department of Urology, University of California Davis, Sacramento.
Br J Urol. 1991 Jan;67(1):44-7. doi: 10.1111/j.1464-410x.1991.tb15068.x.
In a retrospective study we compared the outcome of 39 patients with interstitial cystitis to the histological findings at initial diagnostic bladder biopsy. The degree of inflammation and fibrosis and the mast cell counts were assessed on each biopsy. The prognostic relevance of the clinical features of age, duration of symptoms, frequency, nocturia, pain and bladder capacity was assessed. The study showed no statistical correlation between the severity of histological findings at diagnosis and the eventual outcome of the disease. Over 50% of patients with severe histological abnormalities responded to conservative treatment. Although the majority of patients with mild pathological changes responded to conservative treatment, some did require surgical intervention. The clinical features of pain, nocturia and bladder capacity showed significant differences between the 2 patient groups. However, the former 2 features are subject to many variables and the latter probably has too wide a range to be useful as a prognostic indicator. Only the response of patients to conservative treatment will indicate those who are not being helped and who may eventually require surgical treatment.
在一项回顾性研究中，我们将39例间质性膀胱炎患者的病情转归与初次诊断性膀胱活检的组织学结果进行了比较。对每次活检评估炎症和纤维化程度以及肥大细胞计数。评估了年龄、症状持续时间、尿频、夜尿、疼痛和膀胱容量等临床特征的预后相关性。研究表明，诊断时组织学结果的严重程度与疾病的最终转归之间无统计学相关性。超过50%组织学异常严重的患者对保守治疗有反应。虽然大多数病理改变轻微的患者对保守治疗有反应，但有些患者确实需要手术干预。疼痛、夜尿和膀胱容量等临床特征在两组患者之间存在显著差异。然而，前两个特征受许多变量影响，而后者的范围可能太宽，无法作为预后指标。只有患者对保守治疗的反应才能表明哪些患者没有得到帮助，哪些患者最终可能需要手术治疗。
