Smooth Muscle Laboratory Department of Surgical Sciences School of Veterinary Medicine University of Wisconsin Madison WI USA.
Mediators Inflamm. 1994;3(3):189-97. doi: 10.1155/S0962935194000268.
Capsaicin, substance P, and ovalbumin, instilled into the bladders of naive and ovalbumin (OVA) sensitized guineapigs caused inflammation, as indicated by increased vascular permeability. Histological changes after exposure to these compounds progressed with time from intense vasodilatation to marginalization of granulocytes followed by interstitial migration of leukocytes. In vitro incubation of guinea-pig bladder tissue with substance P and ovalbumin stimulated release of prostaglandin D(2) and leukotrienes. In vitro incubation of bladder tissue with capsaicin, OVA, prostaglandin D(2), leukotriene C(4), histamine, or calcium ionophore A-23587 all stimulated substance P release. These data suggest that bladder inflammation initiated by a variety of stimuli could lead to a cyclic pattern of release of inflammatory mediators and neuropeptides, which could result in amplification and persistence of cystitis after the inciting cause has subsided.
辣椒素、P 物质和卵清蛋白被注入到未致敏和卵清蛋白（OVA）致敏的豚鼠膀胱内，引起炎症，表现为血管通透性增加。暴露于这些化合物后，组织学变化随着时间的推移而发展，从强烈的血管扩张到粒细胞边缘化，随后白细胞间质迁移。将 P 物质和卵清蛋白与豚鼠膀胱组织体外孵育可刺激前列腺素 D2 和白三烯的释放。将辣椒素、OVA、前列腺素 D2、白三烯 C4、组胺或钙离子载体 A-23587 与膀胱组织体外孵育均可刺激 P 物质的释放。这些数据表明，各种刺激物引起的膀胱炎症可能导致炎症介质和神经肽的循环释放，这可能导致刺激物消退后膀胱炎的放大和持续存在。
