Sanchez Pedro L, Mazzone Anna Maria
Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal, 47005, Valladolid, Spain.
Cardiovasc Ultrasound. 2006 Oct 16;4:37. doi: 10.1186/1476-7120-4-37.
Aortic Valve Disease, includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis. It is a slowly progressive active process of valve modification similar atherosclerosis for cardiovascular risk factors, lipoprotein deposition, chronic inflammation, and calcification. Systemic signs of inflammation, as wall and serum CRP, similar to those found in atherosclerosis, are present in patients with degenerative aortic valve stenosis and may be expression of a common disease, useful in monitoring of stenosis progression.
主动脉瓣疾病包括一系列严重程度不同的病症，从无瓣膜梗阻的轻度瓣叶增厚（“主动脉瓣硬化”）到严重的钙化性主动脉瓣狭窄。它是一个缓慢进展的主动瓣膜改变过程，类似于心血管危险因素、脂蛋白沉积、慢性炎症和钙化导致的动脉粥样硬化。与动脉粥样硬化中发现的情况类似，退行性主动脉瓣狭窄患者存在全身炎症体征，如壁和血清中的CRP，这可能是一种常见疾病的表现，有助于监测狭窄进展。
