Richey Luke M, Olshan Andrew F, George Jonathan, Shores Carol G, Zanation Adam M, Cannon Trinitia, Weissler Mark C
General Clinical Research Center and Department of Otolaryngology-Head and Neck Surgery, University of North Carolina Hospitals, Chapel Hill School of Medicine 27599-7600, USA.
Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1035-40. doi: 10.1001/archotol.132.10.1035.
To compare the incidence rates of nasopharyngeal carcinoma (NPC) among US black, white, and Asian/Pacific Islander (Asian) populations, with a focus on those diagnosed before age 20 years and between ages 20 and 29 years. Our secondary objective was to determine differences in survival rates between US blacks, whites, and Asians with NPC who were younger than 30 years.
Data from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) tumor registry system were used to determine incidence and survival rates for cases of NPC diagnosed in the specified age groups between 1973 and 2002.
Blacks, whites, and Asians younger than 30 years with NPC.
Incidence rates and 2- and 5-year survival rates.
From 1973 to 2002, incidence rates per 1 million persons, adjusted to the 2000 standard population, for blacks, whites, and Asians younger than 20 years with NPC were 1.61 (n=43), 0.61 (n=99), and 0.95 (n=18), respectively. The incidence rate ratio of blacks to Asians younger than 20 years was 1.69 (95% confidence interval [CI], 0.96-3.12) (P=.07), while the rate ratio for blacks to whites was 2.66 (95% CI, 1.82-3.85) (P<.001). From ages 20 to 29 years, rates increased slightly in blacks (1.87) and whites (0.96), while increasing dramatically in Asians (7.18). Two- and 5-year relative survival rates in blacks younger than 30 years were 84% and 64%, respectively, with little variation between races in this age group.
Blacks younger than 20 years have increased incidence rates of NPC relative to whites and may be the only group having a higher NPC incidence rate than Asians. Two- and 5-year survival rates of blacks, whites, and Asians younger than 30 years with NPC are similar.
比较美国黑人、白人和亚裔/太平洋岛民（亚裔）人群中鼻咽癌（NPC）的发病率，重点关注20岁之前以及20至29岁之间被诊断出的病例。我们的次要目标是确定30岁以下患有NPC的美国黑人、白人和亚裔之间的生存率差异。
利用美国国立癌症研究所监测、流行病学和最终结果（SEER）肿瘤登记系统的数据，来确定1973年至2002年期间在特定年龄组中被诊断为NPC的病例的发病率和生存率。
30岁以下患有NPC的黑人、白人和亚裔。
发病率以及2年和5年生存率。
从1973年至2002年，按照2000年标准人口调整后，每百万人口中20岁以下患有NPC的黑人、白人和亚裔的发病率分别为1.61（n = 43）、0.61（n = 99）和0.95（n = 18）。20岁以下黑人与亚裔的发病率比为1.69（95%置信区间[CI]，0.96 - 3.12）（P = 0.07），而黑人与白人的发病率比为2.66（95%CI，1.82 - 3.85）（P < 0.001）。在20至29岁年龄段，黑人（1.87）和白人（0.96）的发病率略有上升，而亚裔（7.18）的发病率则大幅上升。30岁以下黑人的2年和5年相对生存率分别为84%和64%，该年龄组不同种族之间的差异不大。
20岁以下的黑人相对于白人，NPC发病率有所上升，并且可能是唯一NPC发病率高于亚裔的群体。30岁以下患有NPC的黑人、白人和亚裔的2年和5年生存率相似。
