美国亚裔/太平洋岛民、白人和黑人中食管癌和胃癌的发病率：亚部位和组织学差异。

Incidence of esophageal and gastric carcinomas among American Asians/Pacific Islanders, whites, and blacks: subsite and histology differences.

作者信息

Wu Xiaocheng, Chen Vivien W, Ruiz Bernado, Andrews Patricia, Su L Joseph, Correa Pelayo

机构信息

Epidemiology Program, School of Public Health/Louisiana Tumor Registry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

出版信息

Cancer. 2006 Feb 1;106(3):683-92. doi: 10.1002/cncr.21542.

DOI:10.1002/cncr.21542

PMID:16388522

Abstract

BACKGROUND

The authors examined subsite-specific and histology-specific esophageal and gastric carcinoma incidence patterns among the Asians/Pacific Islander (API) population in the United States and compared them with those among whites and blacks.

METHODS

Data on newly diagnosed esophageal and gastric carcinomas during 1996-2000 were obtained from 24 population-based central cancer registries, representing approximately 80% of the API population in the United States. Age-adjusted rates, using the 2000 United States standard population, and age-specific rates were computed by anatomic subsite, histology, race, and gender. The difference in the age-adjusted rates between APIs and other races were examined using the two-tailed z statistic.

RESULTS

Greater than 75% of esophageal carcinomas among APIs, both males and females, were squamous cell carcinoma. Adenocarcinoma accounted for <20% of all esophageal carcinomas. This pattern was similar to that among blacks but was completely opposite to that among whites. The rate of esophageal squamous cell carcinoma was 81% higher among API males compared with white males, but it was 64% less compared with black males. The rates of esophageal adenocarcinoma were significantly lower among APIs than among both whites and blacks both males and females. The majority of gastric carcinomas among APIs were noncardia adenocarcinoma, whereas cardia adenocarcinoma accounted for only 11% of gastric carcinomas among API males and 6% of gastric carcinomas among API females. The age-adjusted incidence rate of cardia adenocarcinoma was 23% lower among API males compared with white males, but it was 26% higher compared with black males. In contrast, the rates of noncardia adenocarcinoma among APIs were approximately 3.7 times the rate among whites for both males and females and 33% higher than the rate among blacks.

CONCLUSIONS

Subsite-specific and histology-specific incidence patterns of esophagogastric carcinoma among APIs differ from those among whites and blacks. The reasons for significantly higher rates of noncardia adenocarcinoma among APIs compared with whites and blacks need further investigation.

摘要

背景

作者研究了美国亚裔/太平洋岛民（API）人群中特定亚部位和特定组织学类型的食管癌和胃癌发病模式，并将其与白人和黑人的发病模式进行比较。

方法

1996 - 2000年期间新诊断的食管癌和胃癌数据来自24个基于人群的中央癌症登记处，约占美国API人群的80%。使用2000年美国标准人群计算年龄调整率和年龄别率，按解剖亚部位、组织学类型、种族和性别进行计算。使用双侧z统计量检验API与其他种族之间年龄调整率的差异。

结果

API人群中，无论男性还是女性，超过75%的食管癌为鳞状细胞癌。腺癌占所有食管癌的比例不到20%。这种模式与黑人相似，但与白人完全相反。API男性食管鳞状细胞癌的发病率比白人男性高81%，但比黑人男性低64%。API人群中食管腺癌的发病率在男性和女性中均显著低于白人和黑人。API人群中的大多数胃癌是非贲门腺癌，而贲门腺癌在API男性胃癌中仅占11%，在API女性胃癌中占6%。API男性贲门腺癌的年龄调整发病率比白人男性低23%，但比黑人男性高26%。相比之下，API人群中非贲门腺癌的发病率在男性和女性中约为白人的3.7倍，比黑人高33%。