吡哆醇不能预防大鼠高压氧诱导的癫痫发作。

Pyridoxine does not prevent hyperbaric oxygen-induced seizures in rats.

作者信息

Walter Frank G, Chase Peter B, Fernandez Miguel C, Cameron Diane, Roe Denise J, Wolfson Mark

机构信息

Division of Medical Toxicology, Department of Emergency Medicine, University of Arizona, College of Medicine, Tucson, Arizona, 85724-5057, USA.

出版信息

J Emerg Med. 2006 Aug;31(2):135-8. doi: 10.1016/j.jemermed.2005.09.011.

DOI:10.1016/j.jemermed.2005.09.011

PMID:17044573

Abstract

Normobaric supplemental oxygen can prolong seizures not caused by hyperbaric oxygen therapy. In addition, hyperbaric oxygen therapy can cause seizures. The mechanism of hyperbaric oxygen-induced seizures is unknown. We hypothesized that pretreatment with pyridoxine may delay the onset of hyperbaric oxygen-induced seizures, recognizing that pyridoxine is already an antidote for some epileptogenic poisons such as isoniazid and monomethylhydrazine. Therefore, rats were pretreated with intraperitoneal injections of pyridoxine at 48, 24, and 2 h before undergoing hyperbaric oxygen (HBO) treatment at 3 atmospheres absolute with 100% oxygen and were compared to a control group of HBO-treated rats for time to onset of seizures. There was no difference in onset of seizure time between the pyridoxine-treated group of rats and the control rats. Supplemental pyridoxine pretreatment did not alter the time to onset of seizures during HBO treatment in this study.

摘要

常压补充氧气可延长非高压氧治疗引起的癫痫发作。此外，高压氧治疗可引发癫痫发作。高压氧诱发癫痫发作的机制尚不清楚。我们推测，鉴于吡哆醇已是某些致癫痫毒物（如异烟肼和一甲基肼）的解毒剂，预先使用吡哆醇可能会延迟高压氧诱发癫痫发作的起始时间。因此，在大鼠接受3个绝对大气压的100%氧气高压氧（HBO）治疗前48小时、24小时和2小时，腹腔注射吡哆醇进行预处理，并将其与接受HBO治疗的对照组大鼠进行癫痫发作起始时间的比较。吡哆醇治疗组大鼠和对照大鼠在癫痫发作时间上没有差异。在本研究中，补充吡哆醇预处理并未改变HBO治疗期间癫痫发作的起始时间。