Beckman D L, Crittenden D J, Overton D H, Blumenthal S J
Life Sci. 1982 Jul 5;31(1):45-9. doi: 10.1016/0024-3205(82)90399-x.
Previous evidence suggests a causal relationship between blood glucose levels and the development of generalized epileptiform seizures. In the present study rats were pretreated with glucose, alloxan, or insulin prior to exposure to 6 atmospheres absolute (ATA) oxygen in a hyperbaric chamber. The results showed that the administration of glucose prior to oxygen exposure increased the time-to-seizure by 90% and alloxan by 110%, whereas in contrast insulin decreased the time-to-seizure by 55%. Blood glucose levels were consistently elevated in rats following oxygen exposure. A trend towards reduced lung damage by glucose and alloxan pretreatment was suggested by the data, although no changes were significant. Our results showed that prior administration of glucose or alloxan offered partial protection from oxygen toxicity in rats, whereas insulin generally augmented the reaction.
先前的证据表明血糖水平与全身性癫痫样发作的发生之间存在因果关系。在本研究中，大鼠在高压舱中暴露于6个绝对大气压（ATA）氧气之前，先用葡萄糖、四氧嘧啶或胰岛素进行预处理。结果表明，在氧气暴露前给予葡萄糖使癫痫发作时间增加了90%，给予四氧嘧啶使癫痫发作时间增加了110%，而相比之下，胰岛素使癫痫发作时间减少了55%。氧气暴露后大鼠的血糖水平持续升高。数据表明，葡萄糖和四氧嘧啶预处理有减轻肺损伤的趋势，尽管没有显著变化。我们的结果表明，预先给予葡萄糖或四氧嘧啶可使大鼠部分免受氧毒性，而胰岛素通常会增强这种反应。
