Moshkin A V
Lab Delo. 1990(10):47-50.
The permeability of the blood-liquor barrier (BLB) for blood proteins was studied in 30 patients within 24 hours after craniocerebral injuries of various severity and 21 patients whose condition was critical within 24 hours after different neurosurgical interventions. BLB permeability was assessed from the ratio of albumin/IgG in the cerebrospinal fluid and blood. A direct though not always statistically significant relationship between BLB permeability and the severity of injury was revealed. The authors suppose that this methodological approach, combined with other methods of investigation, may be useful in assessing the course of brain edema. Local IgG synthesis in the central nervous system was detected in half of the injured patients and in half of those in the critical condition. Local immune humoral reaction of the central nervous system appears to be largely related to the trauma severity and not influencing the outcome. This phenomenon is to be verified by specific immunologic methods.
在30例不同严重程度颅脑损伤后24小时内的患者以及21例在不同神经外科手术后24小时内病情危急的患者中，研究了血-脑脊液屏障（BLB）对血液蛋白质的通透性。通过脑脊液和血液中白蛋白/ IgG的比值评估BLB通透性。结果显示BLB通透性与损伤严重程度之间存在直接关系，但并非总是具有统计学意义。作者认为，这种方法与其他调查方法相结合，可能有助于评估脑水肿的病程。在一半的受伤患者和一半病情危急的患者中检测到中枢神经系统局部IgG合成。中枢神经系统的局部免疫体液反应似乎在很大程度上与创伤严重程度有关，而不影响预后。这种现象有待通过特定的免疫学方法加以验证。
