[The permeability of the blood-cerebrospinal fluid barrier in the first 24 hours after cranio-cerebral injury].

The permeability of the blood-liquor barrier (BLB) for blood proteins was studied in 30 patients within 24 hours after craniocerebral injuries of various severity and 21 patients whose condition was critical within 24 hours after different neurosurgical interventions. BLB permeability was assessed from the ratio of albumin/IgG in the cerebrospinal fluid and blood. A direct though not always statistically significant relationship between BLB permeability and the severity of injury was revealed. The authors suppose that this methodological approach, combined with other methods of investigation, may be useful in assessing the course of brain edema. Local IgG synthesis in the central nervous system was detected in half of the injured patients and in half of those in the critical condition. Local immune humoral reaction of the central nervous system appears to be largely related to the trauma severity and not influencing the outcome. This phenomenon is to be verified by specific immunologic methods.