Churliaev Iu A, Nikiforova N V, Lutsik A A, Kuksinskiĭ V A, Lykova O F, Martynenkov V Ia, Karpenko V S
Zh Vopr Neirokhir Im N N Burdenko. 1999 Oct-Dec(4):28-31.
To study blood-brain barrier permeability and proteolytic changes in in patients with severe brain injury and to evaluate their impact on its course and outcome, the concentrations of albumin, plasminogen (plasmin), alpha 2-macroglobulin, alpha 2-antiplasmin, and alpha 1-antitrypsin were examined in 58 victims by enzyme immunoassay. The control group comprised 20 patients examined for lumbar discal hernia. The studies indicate that early severe brain injury showed blood-brain barrier dysfunction whose severity can be detected by the spinal fluid levels of albumin, plasminogen, and alpha 2-macroglobulin. Proteolytic changes in spinal fluid are determined by its albumin, plasminogen (plasmin), alpha 2-macroglobulin, alpha 2-antiplasmin, and alpha 1-antitrypsin concentrations and affect the development of secondary brain lesion and they are of practical value.
为研究重型脑损伤患者血脑屏障通透性及蛋白水解变化，并评估其对病程及预后的影响，采用酶免疫分析法检测了58例患者的白蛋白、纤溶酶原（纤溶酶）、α2-巨球蛋白、α2-抗纤溶酶及α1-抗胰蛋白酶浓度。对照组包括20例接受腰椎间盘突出症检查的患者。研究表明，早期重型脑损伤呈现血脑屏障功能障碍，其严重程度可通过脑脊液中白蛋白、纤溶酶原及α2-巨球蛋白水平检测出来。脑脊液中的蛋白水解变化由其白蛋白、纤溶酶原（纤溶酶）、α2-巨球蛋白、α2-抗纤溶酶及α1-抗胰蛋白酶浓度决定，并影响继发性脑损伤的发展，具有实际价值。
