Martin Michael D, Woods James S
Associate Professor of Oral Medicine, University of Washington, School of Dentistry, Department of Oral Medicine, Box 356370, Seattle, WA 98195, USA.
Expert Opin Drug Saf. 2006 Nov;5(6):773-81. doi: 10.1517/14740338.5.6.773.
The safety of mercury-containing dental amalgam has been hotly debated for well over a century. Dental exposures from mercury have been suggested as the cause of numerous diseases including multiple sclerosis, autism and many others. Known health effects of mercury exposure include CNS and renal damage. However, these effects have only been shown at occupational or higher levels of exposure, and have not been conclusively shown to be present at levels of mercury exposure consistent with that from dental amalgam fillings. The use of mercury amalgam fillings remains a state-of-the-art treatment for dental caries throughout the world. Although there have been a small number of peer-reviewed reports examining the health effects of dental mercury in children, only very recently have the only randomised, controlled clinical trials (two) of the safety of mercury amalgam been published. The purpose of this review is to discuss the scientific evidence on the safety of the use of mercury-containing dental amalgam as a treatment for dental caries.
含汞牙科汞合金的安全性已经激烈争论了一个多世纪。汞的牙科暴露被认为是包括多发性硬化症、自闭症等众多疾病的病因。已知汞暴露对健康的影响包括中枢神经系统和肾脏损害。然而，这些影响仅在职业暴露或更高暴露水平下才会出现，并且尚未确凿证明在与牙科汞合金填充物一致的汞暴露水平下存在这些影响。使用汞合金填充物仍然是全世界治疗龋齿的一种先进方法。虽然有少数经过同行评审的报告研究了儿童牙科汞对健康的影响，但直到最近才发表了仅有的两项关于汞合金安全性的随机对照临床试验。这篇综述的目的是讨论使用含汞牙科汞合金治疗龋齿安全性的科学证据。
