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[激素对大鼠腹侧脊神经根轴突运输速率的影响]

[The effect of hormones on the rate of axonal transport in the ventral spinal nerve roots of rats].

作者信息

Frol'kis V V, Tanin S A, Martsinko V I

出版信息

Neirofiziologiia. 1990;22(4):459-64.

PMID:1704487
Abstract

The Wistar male rats in the age of 8-12 months were injected 7-8 microliter of aqueous solution of L-leucine-14C (specific activity 12543 megaBq/mmol) into the area of the ventral horn at the level of L5,6 segment of the spinal cord. The study of radioactivity in various sections of the respective frontal root was performed after one hour. It was found that estradiol dipropionate, testosterone propionate, insulin and small doses of thyroxin increased the axonal transport of the labelled material, while hydrocortisone, large doses of thyroxin, castration and thyroidectomy caused its delay. It is concluded that the axonal transport is under a pronounced hormonal control.

摘要

选用8 - 12月龄的雄性Wistar大鼠,将7 - 8微升L - 亮氨酸 - 14C水溶液(比活度为12543兆贝可/毫摩尔)注入脊髓L5、6节段腹角区域。1小时后对相应前根各节段的放射性进行研究。结果发现,二丙酸雌二醇、丙酸睾酮、胰岛素和小剂量甲状腺素可增加标记物质的轴突运输,而氢化可的松、大剂量甲状腺素、去势和甲状腺切除则导致其运输延迟。得出的结论是,轴突运输受显著的激素控制。

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Neirofiziologiia. 1990;22(4):459-64.
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