Guillem Pascale, Cans Christine, Guinchat Vincent, Ratel Marc, Jouk Pierre-Simon
Register for Disabled Children and the Isère County Perinatal Survey, France.
Dev Med Child Neurol. 2006 Nov;48(11):896-900. doi: 10.1017/S0012162206001964.
Our aim was to study trends in the prevalence of pervasive developmental disorders (PDD) and to quantify their association with morphogenetic anomalies and with perinatal characteristics such as gestational age, birthweight, and hospitalization in a neonatal care unit. Data from a French morbidity register of childhood disabilities with the use of consistent definitions over time within the same geographical area were analyzed. The data of a total of 454 children (312 males, 142 females) with PDD, born between 1980 and 1993 and residing in Isère county, were recorded at the age of 7 years. The overall prevalence of PDD was 22.2 out of every 10000. There was a significant increase, from 14.7 to 30.8 out of every 10 000, during the period of study. Among these children with PDD, morphogenetic anomalies were observed in 12.1% (95% confidence interval [CI] 9.3-15.5), and the hospitalization rate during the neonatal period was 22% (95% CI 17.0-27.5), which is significantly higher than the observed rates in the general population. The increase in the prevalence of PDD, the association with perinatal risk factors, and the high rate of neonatal hospitalization require further studies to investigate the reasons for and mechanisms of these developmental disorders.
我们的目的是研究广泛性发育障碍（PDD）的患病率趋势，并量化其与形态发生异常以及与围产期特征（如胎龄、出生体重和新生儿重症监护病房住院情况）之间的关联。我们分析了来自法国儿童残疾发病率登记处的数据，这些数据在同一地理区域内随时间使用了一致的定义。记录了1980年至1993年期间出生且居住在伊泽尔省、共454名患有PDD的儿童（312名男性，142名女性）7岁时的数据。PDD的总体患病率为每10000人中有22.2例。在研究期间，患病率从每10000人中有14.7例显著增加至30.8例。在这些患有PDD的儿童中，观察到形态发生异常的比例为12.1%（95%置信区间[CI]9.3 - 15.5），新生儿期住院率为22%（95%CI 17.0 - 27.5），这显著高于普通人群中的观察率。PDD患病率的增加、与围产期危险因素的关联以及新生儿高住院率需要进一步研究以探讨这些发育障碍的原因和机制。
