Wang Youfa, Chen Xiaoli, Klag Michael J, Caballero Benjamin
Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Adv Chronic Kidney Dis. 2006 Oct;13(4):336-51. doi: 10.1053/j.ackd.2006.07.016.
Childhood obesity has become a global epidemic. Childhood obesity has many long-term adverse effects on morbidity and mortality. The prevalence of end-stage renal disease (ESRD) has risen dramatically in the past decade in parallel with the increase in obesity. Our current understanding of the consequences of childhood obesity on kidney function and disease is very limited. The present study presents the worldwide trends in childhood obesity and reviews published studies that have examined the association between obesity and kidney disease in the pediatric and adult populations. A large number of studies have been conducted to examine the association between obesity and kidney disease in general adult populations; however, few have been conducted to examine the impact of childhood obesity on the risk of kidney disease. Findings from large cohort studies in adult general populations show that obesity increases the risk of kidney diseases. Six follow-up studies in pediatric patients were identified, and they indicate that childhood obesity is associated with an increased risk of kidney disease and the progression and mortality of kidney disease. Future studies in the pediatric populations are needed.
儿童肥胖已成为一种全球流行病。儿童肥胖对发病率和死亡率有许多长期不良影响。在过去十年中，终末期肾病（ESRD）的患病率随着肥胖率的上升而急剧上升。我们目前对儿童肥胖对肾功能和疾病影响的了解非常有限。本研究呈现了全球儿童肥胖的趋势，并回顾了已发表的关于儿童和成人肥胖与肾脏疾病之间关联的研究。大量研究已针对一般成年人群中肥胖与肾脏疾病的关联进行了调查；然而，很少有研究探讨儿童肥胖对肾病风险的影响。成年普通人群的大型队列研究结果表明，肥胖会增加患肾病的风险。我们确定了六项针对儿科患者的随访研究，这些研究表明儿童肥胖与肾病风险增加以及肾病的进展和死亡率相关。未来需要针对儿科人群开展研究。
