大麻素激动剂WIN 55,212-2对脊髓损伤大鼠的抗伤害感受作用。
Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.
作者信息
Hama Aldric, Sagen Jacqueline
机构信息
University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace (R-48), Miami, FL 33136, USA.
出版信息
Exp Neurol. 2007 Mar;204(1):454-7. doi: 10.1016/j.expneurol.2006.09.002. Epub 2006 Oct 11.
Abstract
Spinal cord injury (SCI) pain exhibits many symptoms associated with peripheral neuropathic pain, including increased tactile hypersensitivity. One novel approach to ameliorate SCI pain is the use of cannabinoid (CB) ligands. The current study evaluated the efficacy of the nonselective CB receptor agonist WIN 55,212-2 on tactile hypersensitivity in rats following a brief compression to the thoracic spinal cord. The withdrawal thresholds of the hind paws following SCI were significantly decreased, indicating tactile hypersensitivity. Systemic injection of WIN 55,212-2 increased withdrawal thresholds in a dose-dependent manner. Pretreatment with the CB(1) receptor subtype-selective antagonist AM 251 completely abolished the antinociceptive effect of WIN 55,212-2 whereas pretreatment with the CB(2) receptor subtype-selective antagonist AM 630 did not alter the antinociceptive effect of WIN 55,212-2. These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain.
摘要
脊髓损伤（SCI）疼痛表现出许多与周围神经性疼痛相关的症状，包括触觉超敏反应增强。一种改善SCI疼痛的新方法是使用大麻素（CB）配体。本研究评估了非选择性CB受体激动剂WIN 55,212-2对大鼠胸段脊髓短暂压迫后触觉超敏反应的疗效。SCI后后爪的撤足阈值显著降低，表明存在触觉超敏反应。全身注射WIN 55,212-2以剂量依赖性方式提高撤足阈值。用CB1受体亚型选择性拮抗剂AM 251预处理可完全消除WIN 55,212-2的抗伤害感受作用，而用CB2受体亚型选择性拮抗剂AM 630预处理则不会改变WIN 55,212-2的抗伤害感受作用。这些数据表明，CB1选择性激动剂可能是临床SCI疼痛的新型治疗方法。
相似文献
1
Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.大麻素激动剂WIN 55,212-2对脊髓损伤大鼠的抗伤害感受作用。
Exp Neurol. 2007 Mar;204(1):454-7. doi: 10.1016/j.expneurol.2006.09.002. Epub 2006 Oct 11.
2
Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.大麻素受体 2 亚型调节 WIN 55,212-2 在脊髓损伤神经病理性疼痛大鼠中的抗痛觉过敏作用。
Spine J. 2010 Dec;10(12):1049-54. doi: 10.1016/j.spinee.2010.08.015.
3
Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain.脊髓和脊髓上的大麻素-1 受体的激活可导致神经病理性脊髓损伤疼痛大鼠模型中的镇痛。
Brain Res. 2011 Sep 15;1412:44-54. doi: 10.1016/j.brainres.2011.07.031. Epub 2011 Jul 26.
4
Topical cannabinoid antinociception: synergy with spinal sites.局部大麻素抗伤害感受：与脊髓部位的协同作用。
Pain. 2003 Sep;105(1-2):11-6. doi: 10.1016/s0304-3959(03)00068-x.
5
Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain.大麻素受体激动剂WIN 55,212-2在神经性脊髓损伤疼痛大鼠模型中随时间的持续抗伤害感受作用。
J Rehabil Res Dev. 2009;46(1):135-43. doi: 10.1682/jrrd.2008.04.0049.
6
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.大麻素激动剂对神经性疼痛啮齿动物模型中脊髓伤害性神经元的影响。
J Neurophysiol. 2006 Dec;96(6):2984-94. doi: 10.1152/jn.00498.2006. Epub 2006 Aug 30.
7
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury.外周大麻素受体的激活可减轻热损伤引起的皮肤痛觉过敏。
Pain. 2004 Jun;109(3):432-442. doi: 10.1016/j.pain.2004.02.020.
8
Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.脂肪酸酰胺水解酶（FAAH）抑制剂具有药理作用，但对患有神经性脊髓损伤疼痛的大鼠缺乏镇痛效果。
PLoS One. 2014 May 2;9(5):e96396. doi: 10.1371/journal.pone.0096396. eCollection 2014.
9
Physiological evidence of a postsynaptic inhibition of the tail flick reflex by a cannabinoid receptor agonist.大麻素受体激动剂对甩尾反射进行突触后抑制的生理学证据。
Eur J Pharmacol. 2009 Jan 5;602(1):36-40. doi: 10.1016/j.ejphar.2008.10.061. Epub 2008 Nov 9.
10
Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain.非选择性大麻素激动剂WIN 55,212-2在大鼠术后疼痛模型中的外周和中枢作用位点
Br J Pharmacol. 2009 Jun;157(4):645-55. doi: 10.1111/j.1476-5381.2009.00184.x. Epub 2009 Apr 3.
引用本文的文献
1
Licofelone, a Dual COX/LOX Inhibitor, Ameliorates Paclitaxel-Induced Mechanical Allodynia in Rats in a Cannabinoid Receptor-Dependent Manner.利考非洛，一种双重COX/LOX抑制剂，以大麻素受体依赖的方式改善大鼠紫杉醇诱导的机械性异常性疼痛。
Biomedicines. 2024 Jul 11;12(7):1545. doi: 10.3390/biomedicines12071545.
2
Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model.联合非精神活性大麻素成分大麻二酚和β-石竹烯通过在大鼠脊髓损伤模型中与 CB1 相互作用来减轻慢性疼痛。
PLoS One. 2023 Mar 13;18(3):e0282920. doi: 10.1371/journal.pone.0282920. eCollection 2023.
3
Attenuation of SCI-Induced Hypersensitivity by Intensive Locomotor Training and Recombinant GABAergic Cells.强化运动训练和重组GABA能细胞减轻脊髓损伤诱导的超敏反应
Bioengineering (Basel). 2023 Jan 9;10(1):84. doi: 10.3390/bioengineering10010084.
4
Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons.甲磺酸大麻隆 WIN-55,212-2 抑制背根神经节神经元中肿瘤坏死因子-α诱导的一氧化氮合酶表达。
Int J Mol Med. 2018 Aug;42(2):919-925. doi: 10.3892/ijmm.2018.3687. Epub 2018 May 17.
5
Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.黑色素聚集激素在小鼠持续性神经病理性和炎性疼痛中的新型镇痛作用。
Sci Rep. 2018 Jan 15;8(1):707. doi: 10.1038/s41598-018-19145-z.
6
Effects of repeated dosing with mechanistically distinct antinociceptive ligands in a rat model of neuropathic spinal cord injury pain.在一种机械上不同的抗伤害性配体在脊髓损伤神经病理性疼痛大鼠模型中重复给药的效果。
Pharmacol Res Perspect. 2014 Apr;2(2):e00034. doi: 10.1002/prp2.34. Epub 2014 Mar 13.
7
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.脂肪酸酰胺水解酶（FAAH）抑制剂对HIV感觉神经病变大鼠模型中持续性疼痛相关行为的缓解作用
Neuropharmacology. 2015 Aug;95:100-9. doi: 10.1016/j.neuropharm.2014.11.024. Epub 2014 Dec 5.
8
Novel targets for Spinal Cord Injury related neuropathic pain.脊髓损伤相关性神经病理性疼痛的新靶点
Ann Neurosci. 2011 Oct;18(4):162-7. doi: 10.5214/ans.0972.7531.1118413.
9
Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception.大麻素受体配体在伤害感受模型大鼠中的中枢介导的抗伤害感受效应。
Pharmacol Biochem Behav. 2011 Dec;100(2):340-6. doi: 10.1016/j.pbb.2011.09.004. Epub 2011 Sep 17.
10
Cannabinoid agonists inhibit neuropathic pain induced by brachial plexus avulsion in mice by affecting glial cells and MAP kinases.大麻素激动剂通过影响神经胶质细胞和 MAP 激酶抑制臂丛神经根撕脱小鼠的神经病理性疼痛。
PLoS One. 2011;6(9):e24034. doi: 10.1371/journal.pone.0024034. Epub 2011 Sep 13.
本文引用的文献
1
Treatments for chronic pain in persons with spinal cord injury: A survey study.脊髓损伤患者慢性疼痛的治疗：一项调查研究。
J Spinal Cord Med. 2006;29(2):109-17. doi: 10.1080/10790268.2006.11753864.
2
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats.一种大麻素激动剂WIN 55,212-2可减轻紫杉醇诱导的大鼠神经性疼痛。
Pain. 2005 Nov;118(1-2):23-34. doi: 10.1016/j.pain.2005.07.008. Epub 2005 Oct 4.
3
Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.基于大麻的药物治疗多发性硬化症中枢性疼痛的随机对照试验。
Neurology. 2005 Sep 27;65(6):812-9. doi: 10.1212/01.wnl.0000176753.45410.8b.
4
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats.大麻素激动剂WIN 55,212-2对糖尿病大鼠触觉异常性疼痛的影响。
Neurosci Lett. 2004 Nov 23;371(2-3):167-70. doi: 10.1016/j.neulet.2004.08.061.
5
Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial.大麻素屈大麻酚能否减轻多发性硬化症的中枢性疼痛？随机双盲安慰剂对照交叉试验。
BMJ. 2004 Jul 31;329(7460):253. doi: 10.1136/bmj.38149.566979.AE. Epub 2004 Jul 16.
6
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.CB-1和CB-2大麻素受体介导大鼠神经性疼痛中抗伤害感受的证据。
Pain. 2004 May;109(1-2):124-31. doi: 10.1016/j.pain.2004.01.020.
7
Are oral cannabinoids safe and effective in refractory neuropathic pain?口服大麻素对顽固性神经性疼痛是否安全有效？
Eur J Pain. 2004 Apr;8(2):173-7. doi: 10.1016/S1090-3801(03)00084-3.
8
MRI in chronic spinal cord injury patients with and without central pain.伴有和不伴有中枢性疼痛的慢性脊髓损伤患者的磁共振成像
Neurology. 2003 Dec 9;61(11):1569-75. doi: 10.1212/01.wnl.0000096016.29134.fa.
9
Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.合成大麻素CT-3对慢性神经性疼痛的镇痛作用：一项随机对照试验。
JAMA. 2003 Oct 1;290(13):1757-62. doi: 10.1001/jama.290.13.1757.
10
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS.AM1241对CB2大麻素受体的激活可抑制实验性神经病理性疼痛：中枢神经系统中不存在的受体对疼痛的抑制作用。
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10529-33. doi: 10.1073/pnas.1834309100. Epub 2003 Aug 13.
Zotero 插件