Niwa Yoshimitsu, Ito Hidemi, Matsuo Keitaro, Hirose Kaoru, Ito Norio, Mizuno Mika, Hamajima Nobuyuki, Tajima Kazuo, Nakanishi Toru
Department of Gynecology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.
Gynecol Oncol. 2007 Mar;104(3):586-90. doi: 10.1016/j.ygyno.2006.09.007. Epub 2006 Oct 11.
To test the association of endometrial cancer with the lymphotoxin-alpha (LTalpha) C804A and A252G polymorphisms, a hospital-based incident case-control study was performed in Japanese subjects.
The cases comprised 110 endometrial cancer patients, and the controls were 220 age-matched cancer-free females.
The LTalpha C804A and A252G polymorphisms were in complete linkage disequilibrium. We performed conditional logistic regression analysis adjusted for age, which revealed that the LTalpha 252AG and 804CA variant genotypes were associated with a significantly reduced risk of endometrial cancer (OR=0.51, 95% CI=0.31-0.86, P=0.011). Being homozygous of the LTalpha 252G and 804A alleles was not associated with the risk of endometrial cancer. However, the presence of at least one variant LTalpha allele was associated with a significantly lower risk of endometrial cancer (OR=0.54, 95% CI=0.33-0.87, P=0.012). After adjusting for potential confounders (body mass index, age at menarche, parity, hypertension, diabetes mellitus, family history of endometrial cancer, hormone replacement therapy, smoking status, and alcohol consumption), the risk of endometrial cancer was significantly lower both in carriers of one variant allele and in carriers of either one or two of the variant alleles (OR=0.47, 95% CI=0.26-0.85, P=0.017; OR=0.50, 95% CI=0.28-0.89, P=0.019; respectively).
The results suggest that these LTalpha polymorphisms play an important role in the tumorigenesis of endometrial cancer.
为了检测子宫内膜癌与淋巴毒素-α（LTα）C804A和A252G基因多态性之间的关联，在日本受试者中开展了一项基于医院的病例对照研究。
病例组包括110例子宫内膜癌患者，对照组为220名年龄匹配的无癌女性。
LTα C804A和A252G基因多态性处于完全连锁不平衡状态。我们进行了年龄校正的条件逻辑回归分析，结果显示LTα 252AG和804CA变异基因型与子宫内膜癌风险显著降低相关（比值比=0.51，95%可信区间=0.31 - 0.86，P = 0.011）。LTα 252G和804A等位基因纯合状态与子宫内膜癌风险无关。然而，至少存在一个LTα变异等位基因与子宫内膜癌风险显著降低相关（比值比=0.54，95%可信区间=0.33 - 0.87，P = 0.012）。在对潜在混杂因素（体重指数、初潮年龄、产次、高血压、糖尿病、子宫内膜癌家族史、激素替代疗法、吸烟状况和饮酒情况）进行校正后，一个变异等位基因携带者以及一个或两个变异等位基因携带者的子宫内膜癌风险均显著降低（比值比分别为0.47，95%可信区间=0.26 - 0.85，P = 0.017；比值比=0.50，95%可信区间=0.28 - 0.89，P = 0.019）。
结果表明这些LTα基因多态性在子宫内膜癌的肿瘤发生中起重要作用。
