Takei Kako, Ikeda Shinobu, Arai Tomio, Tanaka Noriko, Muramatsu Masaaki, Sawabe Motoji
Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101-0062, Japan.
BMC Cancer. 2008 Aug 13;8:235. doi: 10.1186/1471-2407-8-235.
Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer.
LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy cases and were registered in the Japanese single-nucleotide polymorphisms (SNPs) for geriatric research (JG-SNP) Internet database. Tumors were systematically reviewed, pathologically confirmed, and assessed in relation to LTA genotype.
The study population consisted of 827 males and 709 females, with a mean age of 80 years. Altogether, we studied 606 subjects without cancer and 930 subjects with cancer of the stomach (n = 183), lung (n = 164), colon or rectum (n = 143), or other sites. The presence of cancer was higher in males than in females. The C804A and T495C polymorphisms were associated with cancer in males (CA + AA: CC, adjusted OR = 0.72, 95% CI = 0.53 - 0.99; TC + CC: TT, adjusted OR = 1.45, 95% CI = 1.04 - 2.02; respectively) but not in females. In males, the C804A polymorphism was associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 - 0.97), whereas the T495C polymorphism was associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 - 2.65).
We found some evidence of an association between LTA polymorphisms and cancer risk in elderly Japanese men. Further studies in larger populations should examine this hypothesis.
淋巴毒素-α（LTA）是一种具有抗肿瘤活性的促炎细胞因子。本研究的目的是确定LTA基因多态性是否影响癌症的发生。
在1536例连续尸检病例中测定LTA基因多态性C804A（rs1041981，T60N）和T495C（rs2229094，C13R），并将其登记在日本老年研究单核苷酸多态性（JG-SNP）互联网数据库中。对肿瘤进行系统检查、病理确认，并根据LTA基因型进行评估。
研究人群包括827名男性和709名女性，平均年龄80岁。我们共研究了606名无癌症受试者和930名患有胃癌（n = 183）、肺癌（n = 164）、结肠癌或直肠癌（n = 143）或其他部位癌症的受试者。男性癌症发生率高于女性。C804A和T495C基因多态性与男性癌症相关（CA + AA：CC，校正OR = 0.72，95%CI = 0.53 - 0.99；TC + CC：TT，校正OR = 1.45，95%CI = 1.04 - 2.02），但与女性无关。在男性中，C804A基因多态性与肺癌相关（CA + AA：CC，校正OR = 0.60，95%CI = 0.37 - 0.97），而T495C基因多态性与胃癌相关（TC + CC：TT，校正OR = 1.68，95%CI = 1.06 - 2.65）。
我们发现一些证据表明LTA基因多态性与日本老年男性的癌症风险之间存在关联。应在更大规模人群中进行进一步研究以检验这一假设。
