Singh Amarjit, Grewal G S, Maiti N K, Oberoi M S
Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, India.
Comp Immunol Microbiol Infect Dis. 2006 Nov;29(5-6):315-21. doi: 10.1016/j.cimid.2006.08.001. Epub 2006 Oct 11.
Fowl adenovirus-1 (FAV-1), isolated from field outbreaks of inclusion body hepatitis (IBH), was administered orally to 3-week-old disease-free broiler chicks. Humoral immune competency was evaluated by determining the antibody response of infected chicks to sheep red blood cells (SRBC) and Brucella abortus. FAV-1 infection significantly decreased the antibody response of chicks to B. abortus (T-cell-independent antigen) by decreasing IgM responses, however, the decreased antibody response to SRBC (T-cell-dependent antigen) was statistically non-significant. Bursal index was also found lowered in infected chicks as compared to the control chicks. A significant decrease was seen in blastogenesis response of peripheral blood lymphocytes to phytohaemagglutinin (PHA-P) in FAV-1-infected chicks on 2 and 3 weeks post-infection (WPI). These results indicated that FAV-1 affects humoral as well as cellular immune competency of infected chicks.
从包涵体肝炎（IBH）的田间疫情中分离出的禽腺病毒1型（FAV-1），经口服接种给3周龄无特定病原体的肉鸡雏鸡。通过测定受感染雏鸡对绵羊红细胞（SRBC）和流产布鲁氏菌的抗体反应来评估体液免疫能力。FAV-1感染通过降低IgM反应显著降低了雏鸡对流产布鲁氏菌（非T细胞依赖性抗原）的抗体反应，然而，对SRBC（T细胞依赖性抗原）抗体反应的降低在统计学上不显著。与对照雏鸡相比，受感染雏鸡的法氏囊指数也降低。在感染后第2周和第3周（WPI），FAV-1感染的雏鸡外周血淋巴细胞对植物血凝素（PHA-P）的增殖反应显著降低。这些结果表明，FAV-1影响受感染雏鸡的体液免疫和细胞免疫能力。
