Soppi E, Lassila O, Viljanen M K, Lehtonen O P, Eskola J
Clin Exp Immunol. 1979 Dec;38(3):609-14.
The effect of levamisole in vivo was studied on the PHA and Con A responses of chicken peripheral blood lymphocytes and on the in vivo antibody response to a thymus dependent antigen (BSA) and to a thymus independent antigen (Brucella abortus). Levamisole (0.25 mg/kg) increased significantly both the PHA and Con A responses of chicken blood lymphocytes. The antigens were given at the time of enhanced mitogenic responses and a significant increase was observed in both IgM and IgG antibodies to BSA. In contrast, no effect was obtained on antibody responses to Brucella abortus organisms. The results show that levamisole is able to enhance both humoral and cellular immune responses in normal chickens. The effect is probably mediated by the activation of the T cell function and effects only antibody responses to thymus dependent antigen. These findings confirm and extend the observations regarding the ability of levamisole to modulate immune responses.
研究了左旋咪唑在体内对鸡外周血淋巴细胞的PHA和Con A反应以及对胸腺依赖性抗原（牛血清白蛋白）和胸腺非依赖性抗原（流产布鲁氏菌）的体内抗体反应的影响。左旋咪唑（0.25mg/kg）显著增强了鸡血液淋巴细胞的PHA和Con A反应。在促有丝分裂反应增强时给予抗原，观察到针对牛血清白蛋白的IgM和IgG抗体均显著增加。相比之下，对流产布鲁氏菌的抗体反应未产生影响。结果表明，左旋咪唑能够增强正常鸡的体液免疫和细胞免疫反应。这种作用可能是通过T细胞功能的激活介导的，并且仅影响对胸腺依赖性抗原的抗体反应。这些发现证实并扩展了关于左旋咪唑调节免疫反应能力的观察结果。
