大鼠的社会竞争：细胞增殖与行为
Social competition in rats: cell proliferation and behavior.
作者信息
Hoshaw Brian A, Evans Jennifer C, Mueller Bridget, Valentino Rita J, Lucki Irwin
机构信息
Department of Psychiatry, University of Pennsylvania, USA.
出版信息
Behav Brain Res. 2006 Dec 15;175(2):343-51. doi: 10.1016/j.bbr.2006.09.004. Epub 2006 Oct 11.
Abstract
Behavioral and physiological changes were studied following prolonged exposure to social competition in pairs of non-food-deprived rats competing daily for a limited supply of graham cracker crumbs. Stable dominant-subordinate relationships developed in most pairs, as measured by feeding time, which were maintained over a 5-6-week study period. In other behavioral tests, subordinates demonstrated a decreased latency to immobility in the forced swim test compared with dominants, but no difference in locomotor activity. Subordinates had increased bladder size, decreased adrenal gland size, and a 35% reduction of hippocampus cell proliferation compared with the dominant member. Therefore, prolonged social competition, based on restricted access to palatable substances, produced hierarchies among individuals that were associated with differences in behavior, physiology and hippocampal cell proliferation.
摘要
在非食物匮乏的大鼠成对每天为有限的全麦饼干屑供应进行竞争的情况下，研究了长期暴露于社会竞争后的行为和生理变化。通过进食时间测量，大多数配对中形成了稳定的优势-从属关系，这种关系在为期5至6周的研究期间得以维持。在其他行为测试中，与优势大鼠相比，从属大鼠在强迫游泳测试中表现出不动潜伏期缩短，但运动活动无差异。与优势大鼠相比，从属大鼠膀胱增大、肾上腺减小，海马体细胞增殖减少35%。因此，基于对美味物质获取受限的长期社会竞争在个体间产生了等级制度，这与行为、生理和海马体细胞增殖的差异有关。
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