Bahn Yong-Sun, Mühlschlegel Fritz A
Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea.
Curr Opin Microbiol. 2006 Dec;9(6):572-8. doi: 10.1016/j.mib.2006.09.003. Epub 2006 Oct 11.
Carbon dioxide is not only an important gaseous molecule for maintenance of the biosphere homeostasis, but is also a crucial signalling cue in living cells. Fungal pathogens, including Candida albicans and Cryptococcus neoformans, must adapt to dramatic changes in CO2 levels during colonization and subsequent infection of their human host. Recent reports provide insight into how pathogenic fungi sense environmental CO2 and the role of carbonic anhydrase and fungal adenylyl cyclase in CO2 sensing.
二氧化碳不仅是维持生物圈稳态的重要气体分子，也是活细胞中的关键信号线索。包括白色念珠菌和新型隐球菌在内的真菌病原体，在定殖并随后感染人类宿主的过程中，必须适应二氧化碳水平的巨大变化。最近的报告深入探讨了致病真菌如何感知环境中的二氧化碳，以及碳酸酐酶和真菌腺苷酸环化酶在二氧化碳感知中的作用。
