阿片类药物依赖/戒断的改良“乔伊斯模型”
Modified 'Joyce model' of opioid dependence/withdrawal.
作者信息
Raffa Robert B, Tallarida Ronald J
机构信息
Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Philadelphia PA 19140, USA.
出版信息
Eur J Pharmacol. 2006 Dec 3;551(1-3):54-7. doi: 10.1016/j.ejphar.2006.09.003. Epub 2006 Sep 16.
Abstract
By comprehensive and detailed measurement of the time course of withdrawal signs in rats, Joyce et al. (J. Theo. Biol. 240:531-537, 2006) recently provided a creative quantitative model of the onset of drug dependence based on the requirement of protein synthesis. Because the initial model fit the data imperfectly over the full time course, those authors postulated that additional features would be needed. We report excellent fit of the data (R(2)=0.96) by adding: (1) a transient early phase, and (2) a delay in the buildup of protein.
摘要
通过对大鼠戒断症状时间进程进行全面而详细的测量，乔伊斯等人（《理论生物学杂志》240:531 - 537，2006年）最近基于蛋白质合成的需求，提供了一个关于药物依赖发作的创新性定量模型。由于最初的模型在整个时间进程中对数据的拟合并不完美，这些作者推测还需要其他特征。我们通过增加以下内容报告了对数据的出色拟合（R² = 0.96）：（1）一个短暂的早期阶段，以及（2）蛋白质积累的延迟。
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2
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Br J Pharmacol. 2004 Jan;141(1):55-64. doi: 10.1038/sj.bjp.0705595. Epub 2003 Dec 8.
3
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Proc Soc Exp Biol Med. 1965 Jun;119:381-4. doi: 10.3181/00379727-119-30187.
4
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Neuropsychopharmacology. 2003 Jul;28 Suppl 1:S94-7. doi: 10.1038/sj.npp.1300140.
5
Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice.δ-阿片受体-1和前脑啡肽原基因敲除小鼠中阿片耐受与身体依赖的遗传分离
J Neurosci. 2002 Dec 15;22(24):10906-13. doi: 10.1523/JNEUROSCI.22-24-10906.2002.
6
Active heroin administration induces specific genomic responses in the nucleus accumbens shell.主动给予海洛因会在伏隔核壳中引发特定的基因组反应。
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7
Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice.海洛因在μ-阿片受体缺陷小鼠中诱导的奖赏缺失和运动刺激缺乏。
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8
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9
Genes in drug abuse.
Drug Alcohol Depend. 2001 May 1;62(3):157-62. doi: 10.1016/s0376-8716(00)00231-3.
10
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