异丙肌苷治疗慢性乙型活动性肝炎
Isoprinosine in the treatment of chronic active hepatitis type B.
作者信息
Cianciara J, Laskus T, Gabinska E, Loch T
机构信息
Department of Hepatology, Institute of Infectious and Parasitic Diseases, Warsaw, Poland.
出版信息
Scand J Infect Dis. 1990;22(6):645-8. doi: 10.3109/00365549009027115.
21 patients with chronic active hepatitis B (CAH-B) were treated for 1-2 years with isoprinosine, while another 18 patients served as control group. All patients were initially DNA polymerase (DNAp) and HBeAg positive. Nine (43%) treated patients became persistently negative for DNAp, seroconverted to anti-HBe and showed histological remission on follow-up biopsy. Among simultaneously followed controls 5 (28%) lost DNAp and 4 (22%) also lost their HBeAg. However, only 2 (11%) seroconverted to anti-HBe. Histological improvement was seen in 5 (28%) controls. Thus, it seems that isoprinosine may exert a beneficial effect on the course and outcome of CAH-B.
21例慢性活动性乙型肝炎（CAH - B）患者接受了1 - 2年的异丙肌苷治疗，另有18例患者作为对照组。所有患者最初DNA聚合酶（DNAp）和HBeAg均为阳性。9例（43%）接受治疗的患者DNAp持续转阴，血清转换为抗 - HBe，且随访活检显示组织学缓解。在同期随访的对照组中，5例（28%）DNAp转阴，4例（22%）HBeAg也转阴。然而，只有2例（11%）血清转换为抗 - HBe。5例（28%）对照组患者出现组织学改善。因此，异丙肌苷似乎可能对CAH - B的病程和结局产生有益影响。
Zotero 插件