[Course of chronic virus hepatitis B in children and attempts at modifying its treatment].

60 children with chronic virus hepatitis B were followed from there to nine years. 34 children received isoprinosine, 6 prednisone and 20 children were without any therapy. There were no cases of death. In 2 cases treated with isoprinosine cirrhosis was found. Eight children with chronic active hepatitis (4 treated with isoprinosine, 1 with prednisone, and 3 without any treatment) had histological recovery. Isoprinosine significantly accelerated seroconversion in HBe system in children with chronic active hepatitis but not in children with persistent, hepatitis. Isoprinosine shortened also the time of normalisation of aminotransferases activity children. Prednisone had no influence on the course of chronic active hepatitis B in treated group.