奥氮平诱导体重增加动物模型中收缩压的升高
Elevation of systolic blood pressure in an animal model of olanzapine induced weight gain.
作者信息
Patil Basanagouda M, Kulkarni Nagaraj M, Unger Banappa S
机构信息
Department of Pharmacology and Toxicology, KLES's College of Pharmacy, J N Medical College Campus, Nehru Nagar, Belgaum-590010, Karnataka, India.
出版信息
Eur J Pharmacol. 2006 Dec 3;551(1-3):112-5. doi: 10.1016/j.ejphar.2006.09.009. Epub 2006 Sep 16.
In the present study, we examined the effect of olanzapine on weight gain, systolic blood pressure and metabolic changes in rats. Female Sprague Dawley rats were treated with either vehicle or olanzapine (1 and 2 mg/kg i.p, twice daily) for 20 days. Body weight, food and water intake, systolic blood pressure, plasma glucose, insulin and lipid were measured. Olanzapine (1 and 2 mg/kg) significantly increased the body weight and systolic blood pressure. Whereas, food intake and plasma insulin and insulin resistance index, were elevated only at 1 mg/kg. In conclusion, olanzapine induced weight gain in rats is associated with elevation of systolic blood pressure.
在本研究中，我们检测了奥氮平对大鼠体重增加、收缩压及代谢变化的影响。将雌性斯普拉格-道利大鼠分为两组，分别给予溶媒或奥氮平（腹腔注射，剂量为1和2mg/kg，每日两次），持续给药20天。测量大鼠的体重、食物及水摄入量、收缩压、血浆葡萄糖、胰岛素及脂质水平。奥氮平（1和2mg/kg）显著增加了大鼠体重及收缩压。然而，仅在剂量为1mg/kg时，食物摄入量、血浆胰岛素及胰岛素抵抗指数升高。总之，奥氮平诱导大鼠体重增加与收缩压升高有关。
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