对奥氮平所致体重增加和代谢变化的有益作用。 （你提供的原文“Beneficial effect of on...”中“of”后面似乎缺失了具体内容）
Beneficial effect of on olanzapine-induced weight gain and metabolic changes.
作者信息
Ullagaddi Mrityunjaya B, Patil B M, Khanal Pukar
机构信息
Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010 India.
出版信息
J Diabetes Metab Disord. 2021 Jan 6;20(1):41-48. doi: 10.1007/s40200-020-00695-x. eCollection 2021 Jun.
AIM
The present study aimed to investigate the effect of (ZO) extract on weight gain, food intake, locomotor activity, and lipid and glucose metabolism in olanzapine-treated rats.
METHODS
The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were divided into six groups containing six animals in each. Three doses of extract (100, 200, and 400 mg/kg, p.o.) were co-administered with olanzapine 2 mg/kg i.p for 21 days. Bodyweight and food intake were recorded at the interval of three days and locomotor activity once a week. At the end of the study oral glucose tolerance test was performed followed by the estimation of lipid profile.
RESULTS
Co-administration of hydroalcoholic extract of ZO with olanzapine ameliorated olanzapine-induced weight gain and hyperphagia. Similarly, ZO extract also improved pancreatic β-cell function and glucose and lipid metabolism.
CONCLUSIONS
ZO extract ameliorated olanzapine-induced weight gain and hyperphagia by improving pancreatic β-cell functions and lipid metabolism.
目的
本研究旨在探讨（ZO）提取物对接受奥氮平治疗的大鼠体重增加、食物摄入量、运动活性以及脂质和葡萄糖代谢的影响。
方法
通过将粗干粉在70%（v/v）乙醇中浸渍7天来制备ZO的水醇提取物，过滤并在减压下浓缩。将动物分为六组，每组六只。三种剂量的提取物（100、200和400mg/kg，口服）与2mg/kg腹腔注射的奥氮平联合给药21天。每三天记录一次体重和食物摄入量，每周记录一次运动活性。在研究结束时进行口服葡萄糖耐量试验，随后评估血脂情况。
结果
ZO的水醇提取物与奥氮平联合给药可改善奥氮平诱导的体重增加和食欲亢进。同样，ZO提取物还改善了胰腺β细胞功能以及葡萄糖和脂质代谢。
结论
ZO提取物通过改善胰腺β细胞功能和脂质代谢，减轻了奥氮平诱导的体重增加和食欲亢进。
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