酒精依赖男性中酒精与吸烟对睾酮联合作用的对照研究。
Controlled study on the combined effect of alcohol and tobacco smoking on testosterone in alcohol-dependent men.
作者信息
Walter Marc, Gerhard Urs, Gerlach Manfred, Weijers Heinz-Gerd, Boening Jobst, Wiesbeck Gerhard A
机构信息
Division of Substance Use Disorders, Psychiatric University Clinics, University of Basel, Basel, Switzerland.
出版信息
Alcohol Alcohol. 2007 Jan-Feb;42(1):19-23. doi: 10.1093/alcalc/agl089. Epub 2006 Oct 17.
AIMS
The present study examined the association between pre-treatment drinking and smoking parameters and plasma testosterone levels before and after alcohol withdrawal.
METHODS
A total of 51 alcohol-dependent men and 43 age-matched healthy men were investigated. In alcoholics, free testosterone in plasma was measured on the day of admission, after detoxification and after 6 weeks of sobriety.
RESULTS
While the testosterone level of alcoholic men did not differ from healthy controls at the onset of withdrawal, it was significantly higher for the alcoholics after 6 weeks of sobriety than for the healthy controls. Higher alcohol consumption and higher tobacco use before detoxification led to higher levels of testosterone concentration before and after withdrawal.
CONCLUSIONS
The effect of alcohol and tobacco is cumulative, with higher levels of alcohol and tobacco consumption being associated with higher levels of testosterone before and after alcohol withdrawal.
目的
本研究探讨戒酒前后治疗前饮酒和吸烟参数与血浆睾酮水平之间的关联。
方法
共调查了51名酒精依赖男性和43名年龄匹配的健康男性。对酗酒者，在入院当天、戒毒后和戒酒6周后测量血浆中的游离睾酮。
结果
在戒酒开始时，酗酒男性的睾酮水平与健康对照组无差异，但在戒酒6周后，酗酒者的睾酮水平显著高于健康对照组。戒毒前饮酒量较高和吸烟量较大导致戒酒前后睾酮浓度水平较高。
结论
酒精和烟草的影响是累积性的，较高的酒精和烟草消费量与戒酒前后较高的睾酮水平相关。
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