Immunopathogenesis of IBD: insufficient suppressor function in the gut?
作者信息
Huibregtse I L, van Lent A U, van Deventer S J H
机构信息
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Gut. 2007 Apr;56(4):584-92. doi: 10.1136/gut.2006.103523. Epub 2006 Oct 17.
Abstract
摘要
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Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.只有CD4+CD25高表达T细胞的CD45RA+亚群在体外扩增时能产生均一的调节性T细胞系。
Blood. 2006 Dec 15;108(13):4260-7. doi: 10.1182/blood-2006-06-027409. Epub 2006 Aug 17.
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Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.调节性T细胞抑制全身和黏膜免疫激活以控制肠道炎症。
Immunol Rev. 2006 Aug;212:256-71. doi: 10.1111/j.0105-2896.2006.00423.x.
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