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Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.肿瘤微卫星不稳定性状态作为结肠癌氟尿嘧啶辅助化疗获益的预测指标
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Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?预测结肠癌患者基于5-氟尿嘧啶化疗的临床结果：CpG岛甲基化表型是5-氟尿嘧啶反应性亚组吗？
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1
BRAF mutation and gene methylation frequencies of colorectal tumours with microsatellite instability increase markedly with patient age.微卫星不稳定的结直肠肿瘤的BRAF突变和基因甲基化频率随患者年龄显著增加。
Gut. 2006 Aug;55(8):1213-4. doi: 10.1136/gut.2006.095455.
2
Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications.林奇综合征的表型和基因型异质性：对诊断、监测及管理的意义
Eur J Hum Genet. 2006 Apr;14(4):390-402. doi: 10.1038/sj.ejhg.5201584.
3
Microsatellite instability and colorectal cancer prognosis.微卫星不稳定性与结直肠癌预后
Clin Cancer Res. 2005 Dec 1;11(23):8332-40. doi: 10.1158/1078-0432.CCR-05-1030.
4
Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified.对散发性结直肠癌进行错配修复缺陷的常规检测是合理的。
J Pathol. 2005 Dec;207(4):377-84. doi: 10.1002/path.1851.
5
BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors.结直肠癌中的BRAF突变提示微卫星不稳定肿瘤的两种类型。
Cancer. 2005 Sep 1;104(5):952-61. doi: 10.1002/cncr.21266.
6
Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer.遗传性非息肉病性结直肠癌Ⅲ期结肠癌辅助性5-氟尿嘧啶治疗后的生存率
Int J Cancer. 2004 Apr 10;109(3):468-71. doi: 10.1002/ijc.11712.
7
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer.5-氟尿嘧啶的使用与微卫星不稳定型结直肠癌患者的生存率
Gastroenterology. 2004 Feb;126(2):394-401. doi: 10.1053/j.gastro.2003.12.023.
8
Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases.O6-甲基鸟嘌呤-DNA甲基转移酶启动子的高甲基化可能预测结直肠癌病例化疗后的无复发情况。
Clin Cancer Res. 2003 Nov 1;9(14):5306-12.
9
CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.CpG岛甲基化表型是III期结直肠癌患者从5-氟尿嘧啶治疗中获得生存获益的独立预测指标。
Clin Cancer Res. 2003 Aug 1;9(8):2898-903.
10
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.肿瘤微卫星不稳定性状态作为结肠癌氟尿嘧啶辅助化疗获益的预测指标
N Engl J Med. 2003 Jul 17;349(3):247-57. doi: 10.1056/NEJMoa022289.

Predictive value of microsatellite instability for benefit from adjuvant fluorouracil chemotherapy in colorectal cancer.

作者信息

Iacopetta B, Watanabe T

出版信息

Gut. 2006 Nov;55(11):1671-2.

PMID:17047121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1860101/
Abstract
摘要