Slopsema Roelf L, Kooy Hanne M
Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Phys Med Biol. 2006 Nov 7;51(21):5441-53. doi: 10.1088/0031-9155/51/21/004. Epub 2006 Oct 6.
Field-specific apertures, of sufficient range-absorbing thickness, are used in the majority of proton-therapy treatments today. In current practice, these apertures are modelled as objects of infinitesimal thickness. Such an approximation, however, is not accurate if the aperture edge is close to, or extends over, the beam axis. Practical situations in which this occurs include off-axis patch fields, small apertures, and fields shaped with a multileaf collimator. We develop an extension of the pencil-beam dose model to incorporate the aperture thickness. We derive an exact solution as well as a computationally simpler approximate implementation. The model is validated using measurements of the lateral penumbra. For a set-up with a source size of 2.76 cm, a source-to-axis distance of 227 cm, and a aperture-to-axis distance of 35 cm, the maximum increase in penumbra for a 6 cm thick aperture compared to the thin-aperture model is about 2 mm. The maximum shift in the 95% isodose contour line is larger. The overall effect depends on the aperture thickness, the position of the aperture edge and the intrinsic source size and SAD, but is fairly insensitive to aperture-to-skin distance and depth in patient.
如今,大多数质子治疗中都使用了具有足够射程吸收厚度的特定射野孔径。在当前的实践中,这些孔径被建模为厚度可忽略不计的物体。然而,如果孔径边缘靠近束轴或在束轴上延伸,这种近似就不准确了。出现这种情况的实际情形包括离轴贴片射野、小孔径以及用多叶准直器形成的射野。我们开发了铅笔束剂量模型的扩展,以纳入孔径厚度。我们推导了一个精确解以及一个计算上更简单的近似实现方法。该模型通过横向半影测量进行了验证。对于源尺寸为2.76厘米、源轴距为227厘米以及孔径轴距为35厘米的设置,与薄孔径模型相比,6厘米厚孔径的半影最大增加约为2毫米。95%等剂量轮廓线的最大偏移更大。总体效果取决于孔径厚度、孔径边缘的位置以及固有源尺寸和源轴距,但对孔径到皮肤的距离以及患者体内的深度相当不敏感。