Hebden Jeremy C, Price Ben D, Gibson Adam P, Royle Gary
Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.
Phys Med Biol. 2006 Nov 7;51(21):5581-90. doi: 10.1088/0031-9155/51/21/013. Epub 2006 Oct 16.
A recipe is presented for the manufacture of highly compressible phantoms for diffuse optical tomography. The recipe is based on polyvinyl alcohol (PVA) slime, a viscoelastic fluid which readily deforms under moderate pressure. Scattering particles and absorbing compounds can be added to provide a uniform material with stable and reproducible optical properties. A linear relationship between the concentration of scattering particles (either titanium dioxide or microspheres) and the transport scatter coefficient is demonstrated. Phantoms of an arbitrary size and shape may be produced by containing the slime within a thin latex shell, and a stability over a period of at least 3 months has been established. The deformable phantoms may be used to test and calibrate optical tomography systems designed for use on patients with irregular or variable geometries.
本文介绍了一种用于制造用于扩散光学层析成像的高压缩性体模的方法。该方法基于聚乙烯醇（PVA）黏液，这是一种粘弹性流体，在中等压力下容易变形。可以添加散射颗粒和吸收化合物，以提供具有稳定且可重复光学特性的均匀材料。研究表明，散射颗粒（二氧化钛或微球）浓度与输运散射系数之间存在线性关系。通过将黏液包裹在薄乳胶壳内，可以制造任意尺寸和形状的体模，并且已确定其至少3个月的稳定性。这种可变形体模可用于测试和校准设计用于具有不规则或可变几何形状患者的光学层析成像系统。
