Dipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Via G. Sansone 1, 50019 Sesto Fiorentino, Firenze, Italy.
J Biomed Opt. 2013 Jun;18(6):066014. doi: 10.1117/1.JBO.18.6.066014.
The design of inhomogeneous phantoms for diffuse optical imaging purposes using totally absorbing objects embedded in a diffusive medium is proposed and validated. From time-resolved and continuous-wave Monte Carlo simulations, it is shown that a given or desired perturbation strength caused by a realistic absorbing inhomogeneity of a certain absorption and volume can be approximately mimicked by a small totally absorbing object of a so-called equivalent black volume (equivalence relation). This concept can be useful in two ways. First, it can be exploited to design realistic inhomogeneous phantoms with different perturbation strengths simply using a set of black objects with different volumes. Further, it permits one to grade physiological or pathological changes on a reproducible scale of perturbation strengths given as equivalent black volumes, thus facilitating the performance assessment of clinical instruments. A set of plots and interpolating functions to derive the equivalent black volume corresponding to a given absorption change is provided. The application of the equivalent black volume concept for grading different optical perturbations is demonstrated for some examples.
提出并验证了一种使用嵌入扩散介质中的完全吸收物体设计用于漫射光学成像目的的非均匀体模。通过时间分辨和连续波蒙特卡罗模拟，表明可以通过所谓等效黑体积的小的完全吸收物体（等效关系）近似模拟给定或期望的由特定吸收和体积的实际吸收性不均匀性引起的扰动强度。该概念有两种用途。首先，可以利用一组具有不同体积的黑物体来设计具有不同扰动强度的现实的非均匀体模。此外，它允许在等效黑体积给出的可再现的扰动强度尺度上对生理或病理变化进行分级，从而方便临床仪器的性能评估。提供了一组用于得出与给定吸收变化相对应的等效黑体积的绘图和插值函数。演示了等效黑体积概念在分级不同光学扰动方面的应用，提供了一些示例。
