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沙利度胺对大鼠肝硬化中黏附分子表达的影响。

Effects of thalidomide on the expression of adhesion molecules in rat liver cirrhosis.

作者信息

Lv Peng, Paul Shelley Chireyath, Xiao Yanjv, Liu Shiquan, Luo Hesheng

机构信息

Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan, China.

出版信息

Mediators Inflamm. 2006;2006(4):93253. doi: 10.1155/MI/2006/93253.

DOI:10.1155/MI/2006/93253
PMID:17047296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1618940/
Abstract

This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl(4), and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-alpha mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-alpha mRNA and that of ICAM-1, VCAM-1, and E-selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-alpha signaling pathway to inhibit liver fibrosis.

摘要

本研究旨在评估沙利度胺对肝硬化中黏附分子表达的影响。通过腹腔注射四氯化碳在Wistar大鼠中诱导肝硬化，并通过灌胃给予沙利度胺（10毫克/千克/天或100毫克/千克/天），持续8周。高剂量沙利度胺治疗的大鼠肝脏组织病理学和免疫组织化学显著改善，细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）、E-选择素以及肿瘤坏死因子-α（TNF-α）mRNA和蛋白的表达显著降低。分别观察到TNF-α mRNA与ICAM-1、VCAM-1和E-选择素mRNA表达之间存在密切的正相关。这些结果表明，沙利度胺通过TNF-α信号通路对黏附分子的下调发挥作用，从而抑制肝纤维化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/b2a2a58e5ef6/MI2006-93253.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/a451df98382b/MI2006-93253.001a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/2c7776fed9fa/MI2006-93253.005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/a6f289840080/MI2006-93253.006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/0ef1d3b5c96b/MI2006-93253.007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/4b10e5029cd3/MI2006-93253.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/b2a2a58e5ef6/MI2006-93253.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/a451df98382b/MI2006-93253.001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/781b36448e9a/MI2006-93253.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/b7d45f600587/MI2006-93253.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/3fefbcf71390/MI2006-93253.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/2c7776fed9fa/MI2006-93253.005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/a6f289840080/MI2006-93253.006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/0ef1d3b5c96b/MI2006-93253.007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/4b10e5029cd3/MI2006-93253.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6eb/1618940/b2a2a58e5ef6/MI2006-93253.009.jpg

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