Hartmann Tobias
Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany.
Neurodegener Dis. 2006;3(4-5):305-11. doi: 10.1159/000095271.
Lipids play an important part as risk factors for Alzheimer's disease. This article summarizes the current understanding of the molecular mechanism by which amyloid-beta (Abeta) peptides regulate cholesterol and sphingomyelin metabolism, and how in return cholesterol and sphingomyelin regulate Abeta peptide production. An understanding of the physiological function of amyloid precursor protein processing and Abeta function is critical for the development of future therapeutic approaches, e.g. statin treatment.
脂质作为阿尔茨海默病的风险因素发挥着重要作用。本文总结了目前对β-淀粉样蛋白（Aβ）肽调节胆固醇和鞘磷脂代谢的分子机制的理解，以及胆固醇和鞘磷脂如何反过来调节Aβ肽的产生。了解淀粉样前体蛋白加工的生理功能和Aβ功能对于未来治疗方法（如他汀类药物治疗）的开发至关重要。
