Rockman Matthew V, Kruglyak Leonid
Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA.
Nat Rev Genet. 2006 Nov;7(11):862-72. doi: 10.1038/nrg1964.
A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.
近年来，随着人们认识到传统的连锁分析和关联分析技术可应用于通过微阵列测量的数千个转录本水平，一个全球基因表达遗传分析的新领域应运而生。转录本丰度的遗传剖析揭示了数量性状的结构，为将DNA序列变异与表型变异联系起来提供了一种新方法，并增进了我们对转录调控和调控变异的理解。
