Ring-Dimitriou Susanne, Paulweber Bernhard, von Duvillard Serge P, Stadlmann Monika, LeMura Linda M, Lang Josef, Müller Erich
Department of Sport Science and Kinesiology, University of Salzburg, and Department of Internal Medicine, St. Johanns Hospital, Salzburg, Austria.
Eur J Appl Physiol. 2006 Nov;98(5):472-81. doi: 10.1007/s00421-006-0291-9. Epub 2006 Sep 19.
The purpose of this study was to measure changes in plasma adiponectin (ApN) over 24 months of exercise intervention in middle age adults with a predisposition to metabolic syndrome and to determine if changes in ApN were more affected by physical activity or physical fitness. Thirty-six subjects completed a 24 months home-based exercise program (cycling>or=three times per week, >or=45 min/session at 50-65% of VO2peak). Body composition, blood samples, and physical fitness were studied at baseline and after 12 and 24 months of participation in the study. The prescribed physical activity was monitored via self-reported exercise diary to determine MET levels, hours, and exercise compliance. Two-tailed repeated measures ANOVA and Spearman Rank Correlation Coefficients were used to detect significant differences and associations between the variables. ApN increased significantly (P<0.05) after 12 months in males (n=17; 5.3+/-1.9-7.0+/-3.0 microg ml-1) but not in females (n=9; 8.6+/-3.8-11.5+/-4.0 microg ml-1). The net change in ApN over 24 months was significantly correlated to the net change in VO2peak (physical fitness) (r=0.66; P<0.001), whereas exercise intensity was negatively correlated to DeltaApN over 12 months (r=-0.4; P<or=0.04) and 24 months (r=-0.45; P<or=0.02). Based on our results, an improvement in cardiorespiratory fitness of 15% increased plasma ApN concentration. Our findings suggest that moderate physical activity performed over many months induces positive changes in the plasma ApN concentration in adults with a predisposition to metabolic syndrome.
本研究的目的是测量有代谢综合征倾向的中年成年人在24个月运动干预期间血浆脂联素（ApN）的变化，并确定ApN的变化是受体力活动还是身体素质的影响更大。36名受试者完成了一项为期24个月的居家锻炼计划（骑自行车，每周≥3次，每次≥45分钟，强度为最大摄氧量峰值的50 - 65%）。在研究开始时以及参与研究12个月和24个月后，对身体成分、血液样本和身体素质进行了研究。通过自我报告的运动日记监测规定的体力活动，以确定代谢当量水平、运动时长和运动依从性。采用双尾重复测量方差分析和斯皮尔曼等级相关系数来检测变量之间的显著差异和关联。12个月后，男性（n = 17；5.3±1.9 - 7.0±3.0微克/毫升）的ApN显著增加（P < 0.05），而女性（n = 9；8.6±3.8 - 11.5±4.0微克/毫升）则没有。24个月内ApN的净变化与最大摄氧量峰值（身体素质）的净变化显著相关（r = 0.66；P < 0.001），而运动强度与12个月（r = -0.4；P≤0.04）和24个月（r = -0.45；P≤0.02）期间的ApN变化呈负相关。根据我们的结果，心肺功能提高15%会增加血浆ApN浓度。我们的研究结果表明，在有代谢综合征倾向的成年人中，持续数月的适度体力活动会使血浆ApN浓度产生积极变化。
