Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan.
J Atheroscler Thromb. 2011;18(7):592-5. doi: 10.5551/jat.7625. Epub 2011 Mar 3.
Most studies have reported that circulating levels of adiponectin are negatively correlated with the body mass index (BMI), and hypoadiponectinemia is related to cardiometabolic disorders; however, not all obese subjects have hypoadiponectinemia. The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects.
Sixty-eight obese Korean subjects underwent fat distribution by computed tomography (CT) scan and laboratory tests including circulating total adiponectin levels (APN) and circulating high molecular weight adiponectin levels (HMW-APN).
Log-APN and log-HMW-APN did not correlate with log-BMI either in obese males or females in this study; however, log-APN significantly and negatively correlated with log-VFA both in obese males (r=-0.691, p=0.009) and females (r=-0.319, p=0.002), and log-HMW-APN also correlated negatively with log-VFA both in obese males (r=-0.650, p=0.016) and females (r=-0.370, p=0.005). Log-VFA was a significant determinant of log-APN and log-HMW-APN in obese subjects. In contrast, neither log-APN nor log-HMW-APN was significantly correlated with log-SFA in obese males and females.
The present study demonstrated that APN and HMW-APN correlated with VFA, but not BMI and SFA, in obese subjects, and suggest that hypoadiponectinemia may represent dysfunction of adipose tissue in obesity.
大多数研究报告称，脂联素的循环水平与体重指数（BMI）呈负相关，低脂联素血症与心脏代谢紊乱有关；然而，并非所有肥胖者都存在低脂联素血症。本研究旨在探讨肥胖者的循环脂联素水平和脂肪分布，即皮下脂肪面积（SFA）和内脏脂肪面积（VFA）。
68 名韩国肥胖受试者接受了计算机断层扫描（CT）扫描的脂肪分布检测，并进行了包括循环总脂联素水平（APN）和循环高分子量脂联素水平（HMW-APN）在内的实验室检查。
在本研究中，肥胖男性和女性的 log-APN 和 log-HMW-APN 均与 log-BMI 无相关性；然而，log-APN 与 log-VFA 在肥胖男性（r=-0.691，p=0.009）和女性（r=-0.319，p=0.002）中均呈显著负相关，log-HMW-APN 与 log-VFA 在肥胖男性（r=-0.650，p=0.016）和女性（r=-0.370，p=0.005）中也呈负相关。log-VFA 是肥胖受试者 log-APN 和 log-HMW-APN 的显著决定因素。相反，log-APN 和 log-HMW-APN 与肥胖男性和女性的 log-SFA 均无显著相关性。
本研究表明，APN 和 HMW-APN 与 VFA 相关，而与 BMI 和 SFA 不相关，提示低脂联素血症可能代表肥胖症中脂肪组织的功能障碍。
