Khoobyarian N, Barone F, Sabet T, El-Domeiri A A, Das Gupta T K
J Surg Oncol. 1975;7(5):421-5. doi: 10.1002/jso.2930070514.
Type-2 adenovirus was shown to inhibit the growth of transplantable hamster melanoma in 70% of Syrian hamsters without any injurious effect to the host. Greatest inhibition of tumor formation was seen when animals were injected with 10(6) TCD50 of adenovirus and 2.5 x 10(5) tumor cells, or 10(6) TCD50 of virus and 5.0 x 10(5) tumor cells followed either 1 or 7 days later by a second injection of a similar dose of virus. Significant inhibition in tumor growth was also noted when 2 injections of virus (10(6.2) TCD50/injection) were given on 2 separate occasions as late as 7 and 10 days after the inoculation of tumor cells. The mechanism of tumor inhibition is not known but it could be due to a combination of factors such as viral toxicity, viral oncolysis, and antitumor immunity.
在70%的叙利亚仓鼠中，2型腺病毒被证明可抑制可移植的仓鼠黑色素瘤的生长，且对宿主无任何有害影响。当给动物注射10⁶半数组织培养感染剂量（TCD50）的腺病毒和2.5×10⁵个肿瘤细胞，或10⁶ TCD50的病毒和5.0×10⁵个肿瘤细胞，然后在1天或7天后再注射一次相同剂量的病毒时，可观察到对肿瘤形成的最大抑制作用。当在接种肿瘤细胞后7天和10天这么晚的时间，在两个不同的时间点分别注射两次病毒（每次10⁶.² TCD50）时，也观察到肿瘤生长受到显著抑制。肿瘤抑制的机制尚不清楚，但可能是由于多种因素的综合作用，如病毒毒性、病毒溶瘤作用和抗肿瘤免疫。
