Strohl W A, Rabson A S, Rouse H
Science. 1967 Jun 23;156(3782):1631-3. doi: 10.1126/science.156.3782.1631.
Adenovirus type 12 transforms the fibroblastic BHK21 (baby hamster kidney) cell line into rounded or cuboidal cells that give rise in hamsters to undifferentiated small cell sarcomas indistinguishable from those induced in newborn hamsters by inoculation of the virus itself. In contrast. cells from this line transformed by polyoma virus retain their fibroblastic morphology and induce fibrosarcomas in hamsters. This suggests that the morphology of tumors induced by the adenovirus-transformed cells from this line may be determined by the viral genome and that such mechanism may also explain the remarkably uniform microscopic appearance which seems to characterize tumors induced in hamsters by direct inoculation of adenovirus type 12.
12型腺病毒可将成纤维细胞系BHK21（幼仓鼠肾细胞）转化为圆形或立方形细胞，这些细胞在仓鼠体内会引发未分化的小细胞肉瘤，与通过接种病毒本身在新生仓鼠体内诱导产生的肉瘤难以区分。相比之下，经多瘤病毒转化的该细胞系细胞仍保持其成纤维细胞形态，并在仓鼠体内诱导产生纤维肉瘤。这表明，该细胞系经腺病毒转化后的细胞所诱导肿瘤的形态可能由病毒基因组决定，而且这种机制或许也能解释直接接种12型腺病毒在仓鼠体内诱导产生的肿瘤所具有的显著一致的微观外观特征。
