Nakao Mutsuhiro, Nishikitani Mariko, Nomura Kyoko, Karita Kanae, Yano Eiji
Department of Hygiene and Public Health, School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
J Gastroenterol. 2006 Sep;41(9):855-61. doi: 10.1007/s00535-006-1882-2.
Electrogastrography (EGG) is the noninvasive recording of gastric myoelectrical activity. The purpose of the present study was to assess associations of EGG with risk factors for cardiovascular disease (CVD), autonomic nervous function, hormonal responses, and health-related lifestyles.
EGG was measured in 435 Japanese men, aged 24-39 years, who worked at the same company. In addition to anthropometric measurements and blood examinations, power spectral analysis of heart rate variability in low-frequency (LF; 0.04-0.15 Hz) and high-frequency (HF; 0.15-0.40 Hz) bands was conducted. LF/HF and HF were used as the indicators of sympathetic and parasympathetic nervous activity, respectively. Serum cortisol and catecholamine levels were measured as well.
In univariate analyses, the EGG frequency was associated positively with the serum high-density lipoprotein (HDL) and cholesterol level (both-P < 0.0001) and negatively with age, body mass index (BMI), serum triglyceride level, fasting blood sugar, and diastolic blood pressure (all P < 0.05). The EGG frequency tended to increase with increases in the HF band (P = 0.10) and was not significantly associated with the LF/HF ratio (P = 0.45). Neither hormonal responses nor health-related lifestyle factors such as smoking and alcohol were significant (all P > 0.05). A multivariate analysis indicated that both the HDL cholesterol level and BMI were independent predictors of EGG frequency (both P < 0.05), after adjusting for the significant effects of age, HF, and other CVD factors.
Slowed EGG frequency appeared to be linked with various CVD risk factors, including obesity and low HDL cholesterol levels, in young men.
胃电图（EGG）是对胃肌电活动的无创记录。本研究的目的是评估EGG与心血管疾病（CVD）危险因素、自主神经功能、激素反应及健康相关生活方式之间的关联。
对在同一家公司工作的435名年龄在24至39岁之间的日本男性进行了EGG测量。除了人体测量和血液检查外，还对低频（LF；0.04 - 0.15Hz）和高频（HF；0.15 - 0.40Hz）频段的心率变异性进行了功率谱分析。LF/HF和HF分别用作交感神经和副交感神经活动的指标。同时测量了血清皮质醇和儿茶酚胺水平。
在单因素分析中，EGG频率与血清高密度脂蛋白（HDL）和胆固醇水平呈正相关（两者P < 0.0001），与年龄、体重指数（BMI）、血清甘油三酯水平、空腹血糖和舒张压呈负相关（所有P < 0.05）。EGG频率倾向于随HF频段增加而升高（P = 0.10），与LF/HF比值无显著关联（P = 0.45）。激素反应以及吸烟和饮酒等健康相关生活方式因素均无显著意义（所有P > 0.05）。多因素分析表明，在调整了年龄、HF及其他CVD因素的显著影响后，HDL胆固醇水平和BMI均为EGG频率的独立预测因素（两者P < 0.05）。
在年轻男性中，EGG频率减慢似乎与包括肥胖和低HDL胆固醇水平在内的多种CVD危险因素有关。
Zotero 插件