Kerjaschki Dontscho
Department of Pathology, Medical University of Vienna, Vienna, Austria.
J Nephrol. 2006 Jul-Aug;19(4):403-6.
Successful therapy of acute renal transplant rejection causes rapid loss of interstitial inflammatory infiltrate cells. Here we show that massive lymphatic neoangiogenesis in the transplant parenchyma at this time point provides exit routes for lymphocytes and macrophages. This proliferation is driven by macrophages that express the lymphangiotrophic growth factor VEGF-C. However, the newly formed lymphatic vessels presumably also organize the perivascular lymphocytes into immunologically active follicular structures which are involved in the survival of the transplant.
急性肾移植排斥反应的成功治疗会导致间质炎性浸润细胞迅速减少。我们在此表明，此时移植实质内大量的淋巴管新生为淋巴细胞和巨噬细胞提供了出口途径。这种增殖由表达淋巴管生成生长因子VEGF-C的巨噬细胞驱动。然而，新形成的淋巴管可能也会将血管周围的淋巴细胞组织成具有免疫活性的滤泡结构，这些结构与移植器官的存活有关。
