Akdag Ibrahim, Ersoy Alpaslan, Kahvecioglu Serdar, Gullulu Mustafa, Dilek Kamil
Department of Nephrology, Uludağ University Medical School, Bursa, Turkey.
J Nephrol. 2006 Jul-Aug;19(4):515-7.
Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxication occurring with the administration of clarithromycin.
秋水仙碱是一种有效的抗炎药物。然而，对于需要透析的患者，使用时应格外谨慎。秋水仙碱与大环内酯类药物合用可能会损害秋水仙碱的清除，导致药物暴露过量和中毒。我们报告了2例在使用克拉霉素时发生秋水仙碱中毒的肾衰竭病例。
