Cheng Vincent C C, Ho P L, Yuen K Y
Centre of Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China.
South Med J. 2005 Aug;98(8):811-3. doi: 10.1097/01.SMJ.0000163315.02563.B2.
Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.
尽管秋水仙碱是痛风性关节炎和各种多系统疾病患者常用的药物，但其治疗使用中的安全范围尚未得到充分了解。本报告描述了两例致命的粒细胞缺乏症病例，推测是由秋水仙碱和克拉霉素之间的药物相互作用所致。
